Features of clinical and laboratory diagnosis of rare coagulopathy – acquired hemophilia

Introduction. The formation of circulating autoantibodies capable inhibiting factors the blood coagulation system is accompanied by occurrence spontaneous and/or post-traumatic bleeding in patients without a history previous disorders hemostasis system. One reasons for development such conditions acquired hemophilia. Aim – to present algorithms laboratory diagnosis Main findings. Primary and control therapy disease are carried out based on results studies, decoding interpretation which often causes difficulties due low awareness doctors about tactics managing patients. In hemophilia there no direct relationship between tests clinical manifestations disease, determined kinetics interaction with factor (F) VIII. There «false» vitro decrease activity internal pathway (FIX, FXI FXII), associated effect rapid inhibitor high titers. An important task determination lupus anticoagulant, makes it difficult timely diagnose verify diagnosis.